Background: Botulinum neurotoxin is one of the most versatile and widely used medical products in the world.
Aims: The review's focus is the plastic and dermatologic uses of botulinum neurotoxin currently supported by published data.
Methods: Relevant clinical articles regarding botulinum neurotoxin use in plastic surgery, dermatology, and general esthetic literature were searched and reviewed.
Results: The search yielded 258 studies. Two hundred articles were excluded following title and abstract review. Twenty-one studies were excluded following full-text screening. A total of 37 studies remained and were discussed in this review.
Conclusions: Botulinum neurotoxin is widely used for numerous off-label indications from head to toe. Some uses are well documented, and their safety has been demonstrated in controlled trials, yet most remain poorly researched.
Keywords: Botox; Dysport; aging; botulinum neurotoxin; injectables.
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